Synthesis and in vivo anticonvulsant evaluation of 2-chloroquinolinyl hydrazone derivatives.

Epilepsy is a neurological condition which is characterized by unprovoked seizures resulting from abnormal discharge of cerebral neurons and affecting at least 50 million people worldwide. There is continuing demand for new anticonvulsant agents as it has not been possible to control every kind of seizure with existing antiepileptic drugs. Moreover, conventional antiepileptic drugs exhibited unfavorable side effect profile and failure to adequately control seizures (1ñ3). Searching for compounds with potential anticonvulsant activity we focused our attention on various hydrazones and semicarbazones which have been found to display significant anticonvulsant activity (4ñ6). These compounds were believed to interact at two locations on a putative binding site designated as hydrogen binding domain and hydrophobic binding area as proposed by Dimmock et al. (Figure 1). In their study it is also reported that replacement of aryl group with other hydrophobic SYNTHESIS AND IN VIVO ANTICONVULSANT EVALUATION OF 2-CHLOROQUINOLINYL HYDRAZONE DERIVATIVES